Table 4.

Protein expression level changes of the selected targets in differentiated SH-SY5Y cells.

	6 h				24 h				48 h				72 h
	Mean % ± s.e.m.	n	p, T-t	p, M-W	Mean ± s.e.m.	n	p, T-t	p, M-W	Mean ± s.e.m.	n	p, T-t	p, M-W	Mean ± s.e.m.	n	p, T-t	p, M-W
PRX2					−1.1 ± 17.4	5	0.952	0.095	−24.8 ± 8.6	5	0.044	0.095	3.0 ± 24.3	5	0.909	0.577
PRX3	542.3 ± 72.8	6	0.001	0.002	43.8 ± 21.8	15	0.074	0.096	90.4 ± 61.4	15	0.179	0.319	12.2 ± 14.5	15	0.431	0.319
PRX6	123.8 ± 37.5	11	0.008	0.001	2.3 ± 10.3	16	0.825	0.519	2.7 ± 12.0	16	0.823	0.519	10.6 ± 14.6	17	0.481	0.348
DJ-1	13.9 ± 14.6	5	0.396	1.000	2.5 ± 14.3	6	0.868	0.305	−23.9 ± 7.5	6	0.025	0.040	9.2 ± 22.0	6	0.695	0.305
BLVRA	90.8 ± 29.7	11	0.012	0.007	38.8 ± 21.8	17	0.096	0.348	−7.6 ± 9.7	17	0.445	0.118	33.2 ± 34.3	17	0.347	0.754
DDAH2	75.8 ± 60.9	6	0.269	1.000	37.5 ± 29.5	11	0.116	0.247	40.3 ± 18.9	11	0.016	0.007	9.5 ± 22.6	11	0.582	0.247
TIMP2	216.9 ± 109.7	5	0.119	0.095	76.6 ± 20.2	10	0.004	0.001	70.3 ± 21.7	10	0.010	0.001	37.3 ± 29.7	10	0.240	1.000
MMP14	29.4 ± 11.3	6	0.048	0.002	28.8 ± 19.2	10	0.169	1.000	15.4 ± 17.4	11	0.396	0.247	89.3 ± 39.3	11	0.046	0.007
SEPT2	81.3 ± 48.6	4	0.392	0.219	−28.2 ± 16.6	9	0.039	0.003	10.6 ± 19.3	10	0.913	0.419	90.0 ± 40.9	9	0.097	0.034
ENOA	32.4 ± 40.5	6	0.459	1.000	−5.4 ± 5.1	12	0.313	0.459	13.7 ± 10.2	12	0.204	0.459	−26.2 ± 9.1	12	0.015	<0.000
ENOG					46.4 ± 14.7	5	0.034	0.095	73.3 ± 54.6	5	0.251	0.095	9.2 ± 23.0	5	0.711	0.577
14-3-3γ	111.8 ± 50.2	6	0.076	0.040	22.5 ± 17.6	8	0.241	0.369	29.9 ± 14.1	8	0.071	0.073	11.3 ± 16.8	8	0.521	1.000
14-3-3ε	−16.1 ± 15.5	6	0.347	0.305	42.5 ± 12.1	10	0.006	0.012	21.5 ± 20.2	11	0.312	0.700	−7.1 ± 10.1	11	0.498	0.700

The results are expressed as a Mean %.

Mean %: IL-18 treated/untreated control x100-100.

s.e.m., standard error of mean; n, number of separate repeats.

p, p-value [T-test (paired), T-t; Mann–Whitney U-test, M-W]; significant p-values marked as bold (0.05, 0.01, 0.001).