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. Author manuscript; available in PMC: 2014 Aug 7.
Published in final edited form as: Br J Haematol. 2010 Apr 29;150(1):72–82. doi: 10.1111/j.1365-2141.2010.08211.x

Table 2. Non-haematological toxicities observed by grade, dose, and schedule.

Dosing Schedule Dosage Grade
Ida ∣ Vorinostat N 1 2 3 4
Schedule A 12 mg/m2 ∣ 100 mg 5 25 11 6 1
9 mg/m2 ∣ 100 mg 10 48 20 2 1
Schedule B 12 mg/m2 ∣ 100 mg 3 10 7 3 0
12 mg/m2 ∣ 200 mg 3 13 5 1 0
12 mg/m2 ∣ 300 mg 4 17 4 0 0
12 mg/m2 ∣ 400 mg 10 62 26 4 0
12 mg/m2 ∣ 500 mg 6 33 16 5 0

N represents the number of patients at each dose and schedule. The values under grade represent the numbers of adverse events reported by grade. Ida=Idarubicin. Schedule A is Ida given at 12 mg/m2 IV daily for 3 days with vorinostat given TID for 14 days. Schedule B is Ida given at 12 mg/m2 IV daily for 3 days with vorinostat given TID for 3 days.