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. Author manuscript; available in PMC: 2014 Aug 7.
Published in final edited form as: Br J Haematol. 2010 Apr 29;150(1):72–82. doi: 10.1111/j.1365-2141.2010.08211.x

Table 3. Responses by dose and schedule.

Dosing Schedule Dosage
N CR CRp Marrow Response
Ida ∣ Vorinostat
Schedule A 12 mg/m2 ∣ 100 mg 5 0 0 1
9 mg/m2 ∣ 100 mg 10 1 0 0
Schedule B 12 mg/m2 ∣ 100 mg 3 0 0 0
12 mg/m2 ∣ 200 mg 3 0 0 0
12 mg/m2 ∣ 300 mg 4 1 0 1
12 mg/m2 ∣ 400 mg 10 0 1 1
12 mg/m2 ∣ 500 mg 6 0 0 1
Totals 41 2 1 4

N represents the total number of patients for each dose and schedule. Ida = Idarubicin. Schedule A is Ida given at 12 mg/m2 IV daily for 3 days with vorinostat given for 14 days. Schedule B is Ida given at 12 mg/m2 IV daily for 3 days with vorinostat given for 3 days. CR = Complete Response. CRp = Complete Response without platelet recovery.