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. Author manuscript; available in PMC: 2015 Jul 16.
Published in final edited form as: Vaccine. 2014 May 15;32(33):4206–4213. doi: 10.1016/j.vaccine.2014.04.091

Table 3.

Suggestive HLA allelic associations with rubella vaccine-specific neutralizing antibody responses in the Rochester and San Diego study cohorts.

Rochester cohort San Diego cohort
HLA
locus/antibody
titer
Allele Allele
counts
Median,
NT50/ml
25th
Percentile,
NT50/ml
75th
Percentile,
NT50/ml
p-value Allele
counts
Median,
NT50/ml
25th
Percentile,
NT50/ml
75th
Percentile,
NT50/ml
p-value
Antibody titer (NT50/ml) Overall 1398 57.4 35.4 95.7 2016 66.9 43.9 113.9
HLA-A *24:07 - - - - - 7 55.4 50.7 101.0 0.063
*31:01 41 44.0 31.7 82.2 0.280 56 58.0 37.4 114.0 0.072
*33:03 8 78.8 49.8 119.6 0.137 38 108.3 53.5 145.3 0.039
HLA-B *44:05 5 59.5 39.7 115.4 0.916 6 87.1 61.9 139.0 0.003
*49:01 29 57.9 39.3 78.1 0.807 30 92.7 41.6 123.0 0.046
HLA-C - - - - - - - - - - -
HLA-DPA1 *03:01 - - - - - 30 83.7 60.0 128.3 0.057
*04:01 - - - - - 7 133.7 67.0 167.6 0.008
HLA-DPB1 *06:02 7 83.2 53.1 92.6 0.563 48 75.2 53.4 122.2 0.041
*14:01 22 50.9 42.5 68.9 0.316 19 55.4 41.3 80.5 0.055
HLA-DQB1 *04:02 42 44.4 28.8 63.2 0.006 117 62.5 37.1 104.7 0.188
*05:02 24 56.3 40.7 123.1 0.997 50 79.3 55.4 142.5 0.048
*05:03 36 67.0 38.0 102.0 0.055 52 81.5 54.7 120.7 0.387
HLA-DRB1 *01:02 15 88.0 68.0 113.0 0.099 39 56.6 41.1 100.5 0.244
*04:03 10 76.2 31.6 126.3 0.395 23 122.0 62.0 155.3 0.059
*08:02 - - - - - 50 45.0 32.7 69.5 0.009
*08:04 - - - - - 34 96.7 57.8 150.5 0.065
*11:01 61 60.6 37.6 104.5 0.863 107 54.7 35.1 106.1 0.052
*11:03 11 39.7 30.6 64.2 0.096 11 72.5 55.3 103.6 0.841
*12:01 29 72.4 50.0 115.8 0.030 38 70.5 55.5 130.2 0.485
*13:01 92 53.3 36.4 80.6 0.075 87 62.4 42.1 100.6 0.350
HLA-DQA1 *01:03 99 53.3 35.2 82.5 0.068 118 62.8 39.7 114.5 0.303
*01:04 38 70.4 43.8 111.6 0.046 48 81.5 56.3 116.7 0.152
*06:01 11 53.3 33.7 136.3 0.958 18 99.2 62.8 141.7 0.050

Associations tested using linear regression models using log-transformed antibody levels. Analyses adjusted for age at blood draw quartile, quartiles for age at vaccination, time from most recent vaccination to enrollment, gender, race, and rubella vaccination assay run.

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