Table 3.
Suggestive HLA allelic associations with rubella vaccine-specific neutralizing antibody responses in the Rochester and San Diego study cohorts.
| Rochester cohort | San Diego cohort | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| HLA locus/antibody titer |
Allele | Allele counts |
Median, NT50/ml |
25th Percentile, NT50/ml |
75th Percentile, NT50/ml |
p-value | Allele counts |
Median, NT50/ml |
25th Percentile, NT50/ml |
75th Percentile, NT50/ml |
p-value |
| Antibody titer (NT50/ml) | Overall | 1398 | 57.4 | 35.4 | 95.7 | 2016 | 66.9 | 43.9 | 113.9 | ||
| HLA-A | *24:07 | - | - | - | - | - | 7 | 55.4 | 50.7 | 101.0 | 0.063 |
| *31:01 | 41 | 44.0 | 31.7 | 82.2 | 0.280 | 56 | 58.0 | 37.4 | 114.0 | 0.072 | |
| *33:03 | 8 | 78.8 | 49.8 | 119.6 | 0.137 | 38 | 108.3 | 53.5 | 145.3 | 0.039 | |
| HLA-B | *44:05 | 5 | 59.5 | 39.7 | 115.4 | 0.916 | 6 | 87.1 | 61.9 | 139.0 | 0.003 |
| *49:01 | 29 | 57.9 | 39.3 | 78.1 | 0.807 | 30 | 92.7 | 41.6 | 123.0 | 0.046 | |
| HLA-C | - | - | - | - | - | - | - | - | - | - | - |
| HLA-DPA1 | *03:01 | - | - | - | - | - | 30 | 83.7 | 60.0 | 128.3 | 0.057 |
| *04:01 | - | - | - | - | - | 7 | 133.7 | 67.0 | 167.6 | 0.008 | |
| HLA-DPB1 | *06:02 | 7 | 83.2 | 53.1 | 92.6 | 0.563 | 48 | 75.2 | 53.4 | 122.2 | 0.041 |
| *14:01 | 22 | 50.9 | 42.5 | 68.9 | 0.316 | 19 | 55.4 | 41.3 | 80.5 | 0.055 | |
| HLA-DQB1 | *04:02 | 42 | 44.4 | 28.8 | 63.2 | 0.006 | 117 | 62.5 | 37.1 | 104.7 | 0.188 |
| *05:02 | 24 | 56.3 | 40.7 | 123.1 | 0.997 | 50 | 79.3 | 55.4 | 142.5 | 0.048 | |
| *05:03 | 36 | 67.0 | 38.0 | 102.0 | 0.055 | 52 | 81.5 | 54.7 | 120.7 | 0.387 | |
| HLA-DRB1 | *01:02 | 15 | 88.0 | 68.0 | 113.0 | 0.099 | 39 | 56.6 | 41.1 | 100.5 | 0.244 |
| *04:03 | 10 | 76.2 | 31.6 | 126.3 | 0.395 | 23 | 122.0 | 62.0 | 155.3 | 0.059 | |
| *08:02 | - | - | - | - | - | 50 | 45.0 | 32.7 | 69.5 | 0.009 | |
| *08:04 | - | - | - | - | - | 34 | 96.7 | 57.8 | 150.5 | 0.065 | |
| *11:01 | 61 | 60.6 | 37.6 | 104.5 | 0.863 | 107 | 54.7 | 35.1 | 106.1 | 0.052 | |
| *11:03 | 11 | 39.7 | 30.6 | 64.2 | 0.096 | 11 | 72.5 | 55.3 | 103.6 | 0.841 | |
| *12:01 | 29 | 72.4 | 50.0 | 115.8 | 0.030 | 38 | 70.5 | 55.5 | 130.2 | 0.485 | |
| *13:01 | 92 | 53.3 | 36.4 | 80.6 | 0.075 | 87 | 62.4 | 42.1 | 100.6 | 0.350 | |
| HLA-DQA1 | *01:03 | 99 | 53.3 | 35.2 | 82.5 | 0.068 | 118 | 62.8 | 39.7 | 114.5 | 0.303 |
| *01:04 | 38 | 70.4 | 43.8 | 111.6 | 0.046 | 48 | 81.5 | 56.3 | 116.7 | 0.152 | |
| *06:01 | 11 | 53.3 | 33.7 | 136.3 | 0.958 | 18 | 99.2 | 62.8 | 141.7 | 0.050 | |
Associations tested using linear regression models using log-transformed antibody levels. Analyses adjusted for age at blood draw quartile, quartiles for age at vaccination, time from most recent vaccination to enrollment, gender, race, and rubella vaccination assay run.