Table 4.
Suggestive HLA allelic associations with rubella vaccine-specific IL-6 immune responses in the Rochester and San Diego study cohorts.
| Rochester cohort | San Diego cohort | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| HLA locus/cytokine | Allele | Allele counts | Median, pg/ml | 25th Percentile, pg/ml | 75th Percentile, pg/ml | p-value | Allele counts | Median, pg/ml | 25th Percentile, pg/ml | 75th Percentile, pg/ml | p-value |
| IL-6 (pg/ml) | Overall | 1370 | 3,681 | 3,135 | 4,061 | 1938 | 4,117 | 3,525 | 4,787 | ||
| HLA-A | *02:05 | 9 | 3,953 | 3,015 | 3,975 | 0.073 | 21 | 3,836 | 3,246 | 5,082 | 0.214 |
| *31:01 | 42 | 3,483 | 2,916 | 4,006 | 0.084 | 56 | 3,811 | 3,455 | 4,235 | 0.023 | |
| HLA-B | *14:01 | 11 | 3,367 | 3,008 | 3,936 | 0.408 | 15 | 4,711 | 3,950 | 5,021 | 0.026 |
| *35:01 | 70 | 3,634 | 2,994 | 3,945 | 0.062 | 106 | 3,960 | 3,516 | 4,867 | 0.251 | |
| *41:02 | 6 | 3,710 | 3,382 | 4,185 | 0.051 | 7 | 4,672 | 3,651 | 5,333 | 0.563 | |
| *45:01 | 8 | 4,012 | 3,044 | 4,186 | 0.398 | 35 | 4,302 | 3,415 | 5,071 | 0.028 | |
| *48:01 | - | - | - | - | - | 16 | 4,720 | 3,581 | 5,244 | 0.080 | |
| *49:01 | 30 | 3,964 | 3,668 | 4,566 | 0.017 | 30 | 3,933 | 3,448 | 4,607 | 0.674 | |
| HLA-C | *03:02 | 5 | 3,690 | 3,387 | 3,783 | 0.096 | 14 | 4,185 | 3,612 | 4,919 | 0.198 |
| *04:01 | 139 | 3,620 | 2,994 | 3,970 | 0.060 | 257 | 4,026 | 3,502 | 4,789 | 0.208 | |
| *08:02 | 31 | 3,637 | 3,008 | 4,041 | 0.973 | 74 | 4,418 | 3,817 | 4,942 | 0.015 | |
| *15:02 | 25 | 3,585 | 3,131 | 3,989 | 0.414 | 47 | 3,750 | 3,371 | 4,349 | 0.017 | |
| HLA-DPA1 | *01:03 | 1060 | 3,669 | 3,127 | 4,030 | 0.555 | 1181 | 4,076 | 3,501 | 4,768 | 0.031 |
| *02:02 | 59 | 3,690 | 3,144 | 4,183 | 0.361 | 187 | 4,251 | 3,667 | 4,820 | 0.080 | |
| HLA-DPB1 | *05:01 | 41 | 4,061 | 3,397 | 4,369 | 0.120 | 73 | 4,360 | 3,580 | 5,111 | 0.074 |
| HLA-DQB1 | *04:02 | 41 | 3,650 | 2,981 | 4,085 | 0.221 | 115 | 4,132 | 3,579 | 4,702 | 0.104 |
| *05:01 | 166 | 3,732 | 3,168 | 4,033 | 0.014 | 216 | 4,109 | 3,445 | 4,609 | 0.973 | |
| *05:02 | 23 | 3,746 | 3,094 | 4,306 | 0.526 | 49 | 4,410 | 3,760 | 4,847 | 0.064 | |
| *06:02 | 188 | 3,629 | 3,075 | 3,992 | 0.463 | 234 | 4,209 | 3,474 | 4,702 | 0.083 | |
| HLA-DRB1 | *01:01 | 117 | 3,675 | 3,090 | 4,001 | 0.035 | 100 | 4,071 | 3,433 | 4,560 | 0.389 |
| *01:03 | 13 | 3,542 | 3,024 | 3,983 | 0.008 | 22 | 3,988 | 3,410 | 4,569 | 0.378 | |
| *10:01 | 14 | 3,786 | 3,666 | 4,162 | 0.449 | 23 | 4,527 | 3,386 | 5,200 | 0.001 | |
| *11:01 | 61 | 3,797 | 3,345 | 4,172 | 0.854 | 101 | 4,151 | 3,559 | 4,577 | 0.015 | |
| *15:01 | 190 | 3,619 | 3,058 | 3,989 | 0.882 | 171 | 4,032 | 3,407 | 4,679 | 0.020 | |
| *15:03 | 4 | 3,868 | 3,411 | 3,966 | 0.004 | 48 | 4,255 | 3,614 | 4,574 | 0.549 | |
| *16:01 | 12 | 3,691 | 3,137 | 4,285 | 0.538 | 16 | 4,662 | 3,888 | 4,958 | 0.030 | |
| HLA-DQA1 | *01:01 | 140 | 3,712 | 3,095 | 4,031 | 0.021 | 161 | 4,138 | 3,450 | 4,611 | 0.816 |
| *01:05 | 16 | 3,722 | 3,520 | 4,136 | 0.802 | 44 | 4,186 | 3,602 | 4,925 | 0.037 | |
| *03:01 | 142 | 3,667 | 3,081 | 4,047 | 0.806 | 167 | 4,061 | 3,528 | 4,830 | 0.048 | |
| *04:01 | 46 | 3,725 | 3,122 | 4,091 | 0.061 | 122 | 3,995 | 3,542 | 4,676 | 0.180 | |
Associations tested using linear mixed models using log-transformed antibody levels and inverse-normal transformations for IL-6. Analyses adjusted for age at blood draw quartile, quaritles for age at vaccination, time from most recent vaccination to enrollment, gender, race, and rubella vaccination assay run.