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Hypothesis: RB cells are recruited by leukocytes in the bloodstream via LFA-1:ICAM-1 interactions. This illustration shows a three-step binding mechanism that facilitates the RB-neutrophil aggregate formation. (1) Neutrophils and RB cells are flowing in the microtube; (2) Neutrophils and RB cells interact and form aggregates; (3) The aggregates are firmly arrested to the surface through the neutrophil s-Lex:E-selectin binding.
