(A–C) Observed and Expected (in parentheses) numbers of indicated genotypes at embryonic (day 10.5, 14.5 or 18.5) or postnatal (day 25, weaning) timepoints. Data are included for Jmjd3
Δ/Δ (A), Utx
Δ/y;Jmjd3
+/Δ (B′), Utx
Δ/y;Jmjd3
Δ/Δ (B″ and B′″), Utx
Δ/Δ;Jmjd3
+/
Δ (C′), and Utx
Δ/Δ;Jmjd3
Δ/Δ (C″ and C′″) genotypes. Green regions denote viability and red denotes lethality. Mix denotes a mixed genetic background and B6 has been backcrossed to C57BL6 for >5 generations. Significant deviations from expected allele frequencies as determined by χ2 p-value are: (A) *<0.001, (B) * = 0.005, and (C) *<0.001. (D,E) Embryonic day 10.5 images of (D) male Utx+/y;Jmjd3
+/Δ (D′), Utx+/y;Jmjd3
Δ/Δ (D″), Utx
Δ/
y;Jmjd3
+/Δ (D′″), Utx
Δ/
y;Jmjd3
Δ/Δ (D″″) embryos and (E) female Utx
Δ/Δ (E′) and Utx
Δ/Δ;Jmjd3
Δ/Δ (E″) embryos, B6 background.