Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Aug 7;10(8):e1004507. doi: 10.1371/journal.pgen.1004507

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2014 Shpargel et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

(A–C) Observed and Expected (in parentheses) numbers of indicated genotypes at embryonic (day 10.5, 14.5 or 18.5) or postnatal (day 25, weaning) timepoints. Data are included for Jmjd3 ^Δ/Δ (A), Utx ^Δ/y;Jmjd3 ^+/Δ (B′), Utx ^Δ/y;Jmjd3 ^Δ/Δ (B″ and B′″), Utx ^Δ/Δ;Jmjd3 ^+/ ^Δ (C′), and Utx ^Δ/Δ;Jmjd3 ^Δ/Δ (C″ and C′″) genotypes. Green regions denote viability and red denotes lethality. Mix denotes a mixed genetic background and B6 has been backcrossed to C57BL6 for >5 generations. Significant deviations from expected allele frequencies as determined by χ² p-value are: (A) *<0.001, (B) * = 0.005, and (C) *<0.001. (D,E) Embryonic day 10.5 images of (D) male Utx^+/y;Jmjd3 ^+/Δ (D′), Utx^+/y;Jmjd3 ^Δ/Δ (D″), Utx ^Δ/ ^y;Jmjd3 ^+/Δ (D′″), Utx ^Δ/ ^y;Jmjd3 ^Δ/Δ (D″″) embryos and (E) female Utx ^Δ/Δ (E′) and Utx ^Δ/Δ;Jmjd3 ^Δ/Δ (E″) embryos, B6 background.