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. 2014 Aug 7;10(8):e1004528. doi: 10.1371/journal.pgen.1004528

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© 2014 Mathieson, McVean

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A: The age distribution of haplotypes shared between CHB and CEU estimated with array, sequence and “clean” sequence (with indels and low complexity regions removed; Methods). Coloured dashed lines show the medians of each distribution. The grey stepped line shows relative cross-population coalescence rates estimated by MSMC (S. Schiffels, personal communication), and the grey dashed line shows the earliest date in the oldest time interval where this rate is less that 0.5. In both cases, we assume 30 years per generation and . B: As in A but for haplotypes shared between CHB and MXL, restricted to haplotypes where the MXL individual is inferred to be homozygous for Native American ancestry. C–D: Age distributions inferred using “clean” sequence data, comparable to Figure 3A 3A–B (Note the extended x-axis).

Inline graphic — A: The age distribution of haplotypes shared between CHB and CEU estimated with array, sequence and “clean” sequence (with indels and low complexity regions removed; Methods). Coloured dashed lines show the medians of each distribution. The grey stepped line shows relative cross-population coalescence rates estimated by MSMC (S. Schiffels, personal communication), and the grey dashed line shows the earliest date in the oldest time interval where this rate is less that 0.5. In both cases, we assume 30 years per generation and . B: As in A but for haplotypes shared between CHB and MXL, restricted to haplotypes where the MXL individual is inferred to be homozygous for Native American ancestry. C–D: Age distributions inferred using “clean” sequence data, comparable to Figure 3A 3A–B (Note the extended x-axis).