Table 1.
Parameters used in mathematical model
| Parameter* | Description | Value | Notes or Sources |
|---|---|---|---|
| Nsarc | Number of sarcomeres | 8 | - |
| Nnodes | Number of nodes | 9 | Nnodes = Nsarc + 1 |
| Lsarc | Length of sarcomere | 1.6 ± 0.063 μm (mean ± standard error) | Randomly generated using a normal distribution [17] |
| t0 | Start time | 0 seconds | [17] |
| tf | End time | 600 seconds | [17] |
| td | Time step | 10 seconds | [17] |
| ksarc | Sarcomere stiffness | 33.1 nN/μm | [25] |
| m | Sarcomere mass | 8.25 μg | [19] |
| γ | Dampening parameter of internal viscoelasticity | 0.01 nN-s/μm | Calibration exercise |
| η | Dampening parameter of cytoplasmic drag | 6.5 nN-s/μm | Calibration exercise |
| fc | Maximal myosin contractile force (i.e., maximal fcontract) | 32.7 nN | Calibration exercise |
| a | Amplitude of fluctuation function, y(t) | 0 < a ≤ 1 | Randomly generated using a uniform distribution |
| T | Period of fluctuation function, y(t) | 10 ± 10% minutes for myosin. 4 ± 10% minutes for actin. |
Randomly generated using a normal distribution |
| ϕ | Phase shift of fluctuation function, y(t) | − π ≤ ϕ ≤ π | Randomly generated using a uniform distribution |
*
: Unless otherwise mentioned in the text, all the parameters remain constant throughout all simulations, with the exception of Lsarc, which is generated from a normal distribution.