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. 2014 Aug 7;8(8):e3084. doi: 10.1371/journal.pntd.0003084

Figure 4. Silencing of vATPase or IMPDH results in suppression of DENV infection.

Figure 4

A–B) Silencing of vATPase subunit ac39 (vATP-ac39, AAEL011025), vATPase proteolipid subunit (vATP-V0B, AAEL012113), vATPase subunit f (vATP-f, AAEL002464), and vATPase 16-kDa proteolipid subunit (vATP-16, AAEL000291) reduced DENV titers in the Rock strain, C) in the SIN strain, and D) in the PTri strain. E) Silencing of inosine 5′-monophosphate dehydrogenase (IMPDH, AAEL009273) reduced DENV titers in the Rock strain. F) Silencing of vATPase (vATP-V0B) and IMPDH reduced DENV titers in salivary glands at 14 dpbm. ***; p<0.001, **; p<0.01, Mann-Whitney test. A–F) The red bar indicates a median value of titers. Descriptive statistics for DENV infection assays are presented in supplementary table S2.