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. 2014 Aug 7;9(8):e103505. doi: 10.1371/journal.pone.0103505

Figure 3. Levels of FVIIa-AT generated in vivo in wild-type, EPCR-overexpressing (EPCR-OE), and EPCR-deficient (EPCR-def) mice.

Figure 3

(A) Wild-type, EPCR-OE and EPCR-def mice were injected with rFVIIa (120 µg/kg body weight) intravenously via the tail vein. FVIIa-AT levels in plasma obtained from these mice at 60 min post-rFVIIa administration was measured in an ELISA assay (n = 3–4). (B) Endogenous FVIIa-AT levels. Plasma obtained from wild-type, EPCR-OE and EPCR-def mice that were not subjected to any treatment were used to measure endogenous FVIIa-AT levels. The concentration of FVIIa-AT (ng/ml) reflects ng of FVIIa complexed with AT. ns, not statistically significant as determined in one-way analysis of variance.