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. 2014 Aug 7;9(8):e104392. doi: 10.1371/journal.pone.0104392

Figure 5. Effect of transplantation of MSCs on mouse liver histology.

Figure 5

(A) Survival curve of each group of mice after D-galactosamine/lipopolysaccharide (Gal/LPS) intoxication with or without stem cell administration. Representative images of hematoxylin and eosin (H&E) staining of (B) control, (C, D, E) 1, 3 and 14 days post Gal/LPS treatment, respectively; (F, G, H) 1, 3 and 14 days post Gal/LPS treatment with transplantation of human umbilical cord mesenchymal stem cells (hUCMSCs), respectively; (I, J, K) 1, 3, 14 days post Gal/LPS treatment with induced-differentiation of hepatocytes (i-Hep), respectively; and (L) Double-blind quantification of necrotic area of the hepatic histology of each group. Data were analyzed with ImageJ software and expressed as means ± SEM. Different superscript letters (e.g. a vs. b, or b vs. c) represent a statistically significant difference (p<0.05) between two variables. Magnification 200x.