Figure 4. Comparison of different transgenic mice reveals distinct mechanisms underlie responses to cooling and noxious cold stimuli.

(a) Nav1.7^Advill mice (red columns, n = 8) avoid the 0°C test plate to the same extent as littermate controls (white columns, n = 8) in the thermal place preference test but show a behavioural deficit in the noxious cooling range (14–12°C). (b) Nav1.8-DTA mice (black columns, n = 6) avoid the cooling stimuli to the same extent as littermate controls (white columns, n = 6) in the thermal place preference test but show a trend indicating a behavioural deficit in response to 0°C. Data analysed by two-way analysis of variance followed by a Bonferroni post-hoc test. Results are presented as mean ± S.E.M. * P<0.05 (individual points).