Table 6. Comparison of peak TcB between different genotypes.
Gene | Variant | n | peak TcB, mg/dL | p | p a | |
(mean±standard deviation) | ||||||
UGT1A1 | ||||||
rs887829 | m/m+M/m | 192 | 10.7±2.4 | 0.002 | 0.002 b | |
M/M | 738 | 11.3±2.5 | ||||
(TA)n | m/m+M/m | 190 | 10.7±2.4 | 0.001 | 0.001 b | |
M/M | 750 | 11.3±2.5 | ||||
rs4148323 | m/m+M/m | 321 | 11.8±2.3 | 2.4×10−7 | 2.9×10−7b | |
M/M | 595 | 10.9±2.5 | ||||
rs1018124 | m/m+M/m | 271 | 10.9±2.6 | 0.052 | 0.055 | |
M/M | 488 | 11.3±2.5 | ||||
rs6717546 | m/m+M/m | 445 | 11.0±2.6 | 0.02 | 0.022 | |
M/M | 448 | 11.4±2.4 | ||||
rs11563250 | m/m+M/m | 261 | 11.1±2.5 | 0.229 | 0.246 | |
M/M | 661 | 11.3±2.5 | ||||
rs6719561 | m/m+M/m | 522 | 11.1±2.5 | 0.048 | 0.04 | |
M/M | 378 | 11.4±2.4 | ||||
rs4663972 | m/m+M/m | 240 | 11.1±2.6 | 0.268 | 0.323 | |
M/M | 606 | 11.3±2.5 | ||||
HMOX1 | ||||||
(GT)n | group1 | 574 | 11.2±2.5 | 0.893 | 0.77 | |
group2 | 362 | 11.2±2.5 | ||||
rs9607267 | m/m+M/m | 664 | 11.2±2.5 | 0.753 | 0.934 | |
M/M | 265 | 11.2±2.4 | ||||
rs2071749 | m/m+M/m | 434 | 11.2±2.5 | 0.488 | 0.671 | |
M/M | 468 | 11.3±2.5 |
m:minor allele; M:major allele.
Adjusted for gestational age, birth season, delivery mode, birth weight and gender.
Retained significance after the FDR adjustment (<0.05×3/11).