Table 2.
Distribution of XRCC3 and XRCC4 single-nucleotide polymorphisms and their associations with non-small-cell lung cancer in Han population
| Locus | Case (%) (n = 507) | Control (%) (n = 662) | Unadjusted odds ratios (95% confidence intervals) | Adjusted odds ratios* (95% confidence intervals) | Ptrend-value |
|---|---|---|---|---|---|
| XRCC3 | |||||
| rs861539 (PHWE = 0.99) | 507 | 660 | 0.692 | ||
| CC | 450 (88.8%) | 589 (89.2%) | 1 | 1 | |
| CT | 54 (10.7%) | 69 (10.5%) | 1.02 (0.70–1.49) | 1.12 (0.83–1.51) | |
| TT | 3 (0.5%) | 2 (0.3%) | 1.96 (0.33–11.80) | 1.10 (0.73–1.65) | |
| CT +TT | 57 (11.2%) | 71 (10.8%) | 1.05 (0.73–1.52) | 1.10 (0.72–1.68) | |
| rs1799796 (PHWE = 0.07) | 455 | 652 | 0.175 | ||
| AA | 174 (34.3%) | 276 (42.3%) | 1 | 1 | |
| AG | 206 (40.6%) | 280 (42.9%) | 1.17 (0.90–1.52) | 1.11 (0.82–1.49) | |
| GG | 75 (34.3%) | 96 (14.8%) | 1.24 (0.87–1.77) | 1.09 (0.73–1.64) | |
| AG +GG | 281 (61.8%) | 376 (57.7%) | 1.19 (0.93–1.51) | 1.10 (0.83–1.46) | |
| rs861537 (PHWE = 0.16) | 507 | 660 | 0.001 | ||
| GG | 147 (29.0%) | 254 (38.5%) | 1 | 1 | |
| AG | 255 (50.3%) | 297 (45.0%) | 1.48 (1.14–1.93) | 1.44 (1.06–1.94) | |
| AA | 105 (20.7%) | 109 (16.5%) | 1.66 (1.19–2.33) | 1.53 (1.04–2.25) | |
| AG +AA | 360 (71.0%) | 406 (61.5%) | 1.53 (1.20–1.96) | 1.46 (1.10–1.94) | |
| rs1799794 (PHWE = 0.18) | 507 | 661 | 0.002 | ||
| AA | 180 (35.5%) | 184 (27.8%) | 1 | 1 | |
| AG | 230 (45.4%) | 313 (47.4%) | 0.75 (0.58–0.98) | 0.80 (0.59–1.09) | |
| GG | 97 (19.1%) | 164 (24.8%) | 0.61 (0.44–0.84) | 0.60 (0.41–0.87) | |
| AG +GG | 327 (64.5%) | 477 (72.2%) | 0.70 (0.55–0.90) | 0.73 (0.55–0.98) | |
| XRCC4 | |||||
| rs6869366 (PHWE = 0.94) | 501 | 651 | 0.009 | ||
| TT | 437 (87.2%) | 599 (92.1%) | 1 | 1 | |
| TG | 63 (12.6%) | 51 (7.8%) | 1.69 (1.15–2.50) | 1.85 (1.17–2.92) | |
| GG | 1 (0.2%) | 1 (0.1%) | 1.37 (0.09–21.97) | 2.12 (0.12–36.72) | |
| TG +GG | 64 (12.8%) | 52 (7.9%) | 1.69 (1.15–2.48) | 1.86 (1.18–2.91) | |
| rs3734091 (PHWE = 0.14) | 505 | 654 | 0.397 | ||
| CC | 443 (87.7%) | 583 (89.1%) | 1 | 1 | |
| CA | 61 (12.1%) | 71 (10.9%) | 1.13 (0.79–1.63) | 1.08 (0.71–1.65) | |
| AA | 1 (0.2%) | 0 (0.0%) | – | – | |
| CA +AA | 62 (12.3%) | 71 (10.9%) | 1.15 (0.80–1.65) | 1.12 (0.73–1.69) | |
| rs1056503 (PHWE = 0.16) | 504 | 652 | 0.004 | ||
| GG | 281 (55.8%) | 312 (47.9%) | 1 | 1 | |
| GT | 197 (39.1%) | 289 (44.3%) | 0.76 (0.59–0.97) | 0.70 (0.53–0.93) | |
| TT | 26 (5.2%) | 51 (7.8%) | 0.57 (0.34–0.93) | 0.65 (0.37–1.16) | |
| GT +TT | 223 (44.2%) | 340 (52.1%) | 0.73 (0.58–0.92) | 0.70 (0.53–0.91) | |
| rs9293337 (PHWE = 0.88) | 452 | 654 | 0.007 | ||
| TT | 251 (55.5%) | 316 (48.3%) | 1 | 1 | |
| CT | 173 (38.3%) | 276 (42.2%) | 0.79 (0.61–1.02) | 0.74 (0.55–0.99) | |
| CC | 21 (4.6%) | 62 (9.5%) | 0.57 (0.35–0.92) | 0.57 (0.31–0.98) | |
| CT +CC | 194 (42.9%) | 338 (51.7%) | 0.75 (0.59–0.95) | 0.71 (0.54–0.93) | |
Abbreviations: HWE, Hardy–Weinberg equilibrium; XRCC3, X-ray repair cross-complementing group 3; XRCC4, X-ray repair cross-complementing group 4.
*
Adjusted by age, gender, education, family history of lung cancer, smoking status, environmental tobacco smoke, and mental and marital status.
Bold numerals: A P-value of <0.05 was considered statistically significant.