. Author manuscript; available in PMC: 2014 Oct 1.

Published in final edited form as: J Hum Genet. 2013 Aug 8;58(10):679–685. doi: 10.1038/jhg.2013.78

Table 3.

Distributions of XRCC3 and XRCC4 diplotypes and haplotypes and their associations with non-small-cell lung cancer in Han population

Haplotype	Frequency (%)		Diplotype	Frequency (%)		Odds ratios	P-value
Haplotype	Case	Control	Diplotype	Case	Control	95% confidence intervals^a	P-value
XRCC3 (rs861539–rs1799796–rs861537–rs1799794)(P_{permutation test} = 0.001)
CAGG	38.6	45.3	CAGG/CAGG	20.3	27.3	1
CGAA	36.7	31.3	CAGG/CGAA	30.2	31.5	1.21 (0.84–1.74)	0.311
CAGA	14.5	12.2	CGAA/CGAA	15.4	10.4	1.93 (1.21–3.07)	0.006
TAAA	5.5	4.7	CAGA/CAGG	11.0	12.1	1.33 (0.82–2.15)	0.245
Others^b	4.7	6.5	CAGA/CGAA	13.6	10.0	1.82 (1.13–2.96)	0.015
			CAGG/TAAA	5.7	3.5	2.07 (1.05–4.08)	0.036
			CAGA/TAAA	1.4	1.1	3.11 (0.93–10.35)	0.065
			Others^c	2.4	4.1	0.68 (0.30–1.54)	0.352
XRCC4 (rs3734091–rs1056503)(P_{permutation test} = 0.013)
CG	70.8	66.8	CG/CG	49.1	44.1	1
CT	22.9	27.9	CG/CT	34.5	39.4	0.76 (0.56–1.02)	0.067
AG	4.5	3.3	CG/AG	6.9	4.6	1.39 (0.76–2.52)	0.285
AT	1.8	2.0	CT/CT	4.2	5.7	0.67 (0.35–1.27)	0.220
			CG/AT	4.1	4.2	0.63 (0.33–1.21)	0.164
			Others	1.2	2.0	1.10 (0.35–3.46)	0.876

Abbreviations: XRCC3, X-ray repair cross-complementing group 3; XRCC4, X-ray repair cross-complementing group 4.

Bold numerals: A P-value of <0.05 was considered statistically significant.

Adjusted by age, gender, education, family history of lung cancer, smoking status, environmental tobacco smoke, and mental and marital status.

Frequency <5%.

Frequency <2%.