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. 2014 Aug 7;9(8):e104311. doi: 10.1371/journal.pone.0104311

Table 2. Results of the evolutionary conservation analyses using the ConSurf server.

Conservation score
dbSNP Amino acid change SWISS-PROT UniProt UniRef90
rs200555543 F499C 6 5 5
rs147547282 Y275C 5 5 4
rs146655862 V129M 9 9 9
rs72554626 T498A 7 8 8
rs5317 F487V 7 9 9
rs5315 V403E 9 9 8

A conservation score between 1–4 is considered variable; 5–6 is intermediate; 7–9 is conserved.