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. 2014 Aug 7;9(8):e104293. doi: 10.1371/journal.pone.0104293

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© 2014 Witek et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) F-IHC analysis of 293T cells transiently transfected with MSCV-CDX2-Flag or MSCV-CDX2/AS-His revealed diffuse and focal nuclear localization patterns for CDX2 and CDX2/AS, respectively, with minimal areas of overlap (dotted circles). (B) F-IHC analysis of 293T cells transiently transfected with MSCV-CDX2-Flag, MSCV-CDX2/AS-His revealed nuclear localization whereas MSCV-CDX2/ASΔRS-His, a mutant CDX2/AS protein lacking bases distal to the alternatively induced frameshift, resulted in peri-nuclear localization.