Table 1.
Impact of excluding self-reported events on the effects of calcium with or without vitamin D on the risk of myocardial infarction and stroke.
| Trials (n) | Myocardial infarction |
Stroke |
|||
|---|---|---|---|---|---|
| Hazard ratio/relative risk (95% CI) | p | Hazard ratio/relative risk (95% CI) | p | ||
| Calcium monotherapy | |||||
| Patient-level data | |||||
| All studies | 5 | 1.31 (1.02–1.67) | 0.035 | 1.20 (0.96–1.50) | 0.11 |
| Excluding self reports | 4 | 1.44 (1.08–1.91) | 0.013 | 1.20 (0.91–1.59) | 0.19 |
| Trial-level data | |||||
| Studies with complete data | 8 | 1.27 (1.01–1.59) | 0.038 | 1.12 (0.92–1.36) | 0.25 |
| With Prince study coding data | 8 | 1.25 (0.99–1.57) | 0.061 | 1.17 (0.96–1.43) | 0.12 |
| Excluding self reports | 6 | 1.33 (1.03–1.73) | 0.030 | 1.18 (0.93–1.50) | 0.18 |
| Calcium with/without vitamin D | |||||
| Patient-level data | |||||
| All studies | 6 | 1.26 (1.07–1.47) | 0.005 | 1.19 (1.02–1.39) | 0.026 |
| Excluding self reports | 5 | 1.29 (1.10–1.52) | 0.002 | 1.19 (1.01–1.41) | 0.04 |
| Trial-level data | |||||
| Studies with complete data | 9 | 1.24 (1.07–1.44) | 0.004 | 1.15 (1.00–1.32) | 0.055 |
| With Prince study coding data | 9 | 1.23 (1.06–1.43) | 0.006 | 1.18 (1.02–1.36) | 0.026 |
| Excluding self reports | 7 | 1.26 (1.08–1.48) | 0.004 | 1.18 (1.01–1.38) | 0.038 |
For analyses that include Prince study coding data, we updated the data provided by the authors from their trial [Prince et al. 2006] with their subsequent secondary analysis using coding data [Lewis et al. 2011, 2012a]. CI, confidence interval.