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Categorization of drug–drug interactions based on mechanism.
| Mechanism | Number of interactions (n = 856) | Percentage | p value |
|---|---|---|---|
| Pharmacokinetic drug-drug interactions | 361 | 42 | – |
| Absorption | 135 | 16 | |
| Distribution | 3 | 1 | |
| Metabolism | 166 | 19 | <0.05 |
| Excretion | 57 | 7 | |
| Pharmacodynamic drug-drug interactions | 206 | 24 | – |
| Unknown mechanism | 289 | 34 | – |
