Table 5.

Management requirements for the drug–drug interactions documented.

Management	Number of drug–drug interactions (n = 856)
Dosage adjustment	102 (12%)
No management required	94 (11%)
Monitor for signs and symptoms	93 (11%)
Monitor for drug levels	79 (9%)
Monitor for biochemical parameters	74 (9 %)
Change dosing interval	64 (8%)
Avoid the combination	62 (7%)
Monitor for electrolyte levels	60 (7%)
Monitor for patient response	54 (6%)
Monitor for signs and symptoms and biochemical parameters	42 (5%)
Monitor for serum creatinine levels	41 (4%)
Dose titration	28 (3%)
Monitor for signs and symptoms and drug level	23 (3 %)
Monitor for patient response and dose adjustment	17 (2%)
Monitor for drug level and biochemical parameters	13 (2%)
Monitor for electrolyte and drug level	10 (1%)