Table 1.
Characteristics of monoclonal antibodies against FMDV/O and their binding sites
| Clone Name | Isotype | Immunization Ag | VNT results | Reactivity to recombinant protein | Antigenic Sites | Binding sites |
|---|---|---|---|---|---|---|
| F1140O2-5 |
IgG1/k |
O1 Campos |
- |
- |
- |
VP3 V73 |
| F11VP2O-2 |
IgG1/k |
Rec VP2 |
- |
VP2 |
- |
VP2 133QK134 |
| F12VP1O-2 |
IgG1/k |
Rec VP1 |
- |
VP1 |
Site1b |
VP1 198EARHKQKIVAPVKQTL213 |
| F21-48 |
IgG2a/k |
O1 BFS |
+ |
VP1 |
Site1a,5 |
VP1 148 L |
| F21-64 |
IgG2a/k |
O1 BFS |
+ |
VP1 |
Site1a,5 |
VP1 136YSRNAVPNLRGDLQVL151 |
| F21-34 |
IgG2b/k |
O1 BFS |
+ |
- |
Near site2 |
VP2 68D |
| F21-58 |
IgG2b/k |
O1 BFS |
+ |
- |
Site2 |
VP2 77R |
| F21-41 |
IgG2b/k |
O1 BFS |
+ |
- |
Site3 |
VP1 43TP44 |
| F21-18 | IgG2a/k | O1 BFS | + | - | Near site4 | VP3 59G |
-: Negative result; +: Positive result.