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. 2014 Jul 29;13:181. doi: 10.1186/1476-4598-13-181

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Copyright © 2014 Zhang et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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ISL-1 enhances xenografted lymphoma development in vivo. (A to D) NOD-SCID (nonobese diabetic/severe combined immunodeficient) mice were injected s.c. with different NHL cells that were stably transfected with pcDNA3.1 (Control), or pcDNA3.1-ISL-1 (ISL-1) construct (A,C), pLL3.7-Non-silencer or pLL3.7-ISL1-siRNA plasmid (B,D). The tumor size was monitored at indicated days post-injection. Statistical analysis was carried out with 2-way ANOVA. (E) The mice were killed after the last measurement of tumor volume, whole-cell lysate of 2 tumor samples of each group were prepared and subjected to Western blot analysis for ISL-1 level detection. GAPDH served as an internal control.