Figure 2. Treatment-associated autoantibody responses correlate with increased likelihood of biochemical failure. Kaplan-Meier analysis of biochemical failure-free survival according to development of an autoantibody response. Sera from prostate cancer patients (n = 23) receiving androgen-deprivation and external beam radiation bimodal therapy were evaluated for the presence of autoreactive antibodies and plotted according to biochemical failure, as indicated by elevated prostate specific antigen (PSA). Autoantibody-positive subjects are indicated with a solid line and autoantibody-negative subjects are indicated with a dashed line. Check marks indicate censored subjects. A log-rank test was performed to determine the P value.