. 2014 May 8;5:e29019. doi: 10.4161/sgtp.29019

Table 1. Aberrant Rho GTPase expression in cancer.

Rho GTPase	Deregulation	Tumor type
RhoA	Overexpression	Testicular cancer,⁵ breast,⁶^,⁷ colon,⁷ lung,⁷ liver,⁹ head and neck squamous cell carcinoma,⁸ hepatocellular carcinoma,²³¹ bladder,²³² esophageal squamous cell carcinoma,²³³ ovarian carcinoma,²³⁴ gastric carcinoma²³⁵
RhoB	Overexpression	Breast cancer⁶^,⁷
	Downregulation	Squamous cell carcinoma¹⁰
	Loss of expression	Lung cancer¹¹
RhoC	Overexpression	Melanoma,¹⁴ inflammatory breast cancer,¹² breast cancer,⁶^,⁷^,²³⁶ colorectal carcinoma,¹³ pancreatic ductal adenocarcinoma,¹⁵ non-small cell lung carcinoma,²³⁷ gastric cancer,²³⁸ hepatocellular carcinoma,²³⁹ prostate cancer,²⁴⁰ head and neck squamous cell carcinoma,²⁴¹ squamous cell carcinoma of the skin,²⁴² bladder cancer,²³² esophageal squamous cell carcinoma,²³³ ovarian carcinoma²³⁴
Rac1	Overexpression	Testicular cancer,⁵ breast cancer,⁷ leukemia,¹⁶ gastric carcinoma,²³⁵ prostate cancer²⁴³
Rac1	Alternative splicing, Rac1b	Breast,¹⁸ colon carcinoma,¹⁷ non-small cell lung cancer¹⁹
Cdc42	Overexpression	Non-small cell lung cancer,²² colorectal adenocarcinoma,²³ melanoma,²⁴ breast,⁶^,⁷ testicular cancer⁵