Table 2. Rho GTPase mutations in cancer.

Rho GTPase	Mutation	Tumor type
Rac1	Deletions, frame shift and point mutations	Brain cancer31
	P29S	Melanoma27,28
	N92I	HT1080 fibrosarcoma cell line33
	C157Y	Lung adenocarcinoma33
Rac2	P29L	Melanoma27 HCC1143 breast cancer cell line33
	P29Q	KCL-22 chronic myeloid leukemia cell line33
Cdc42	G12D	Melanoma27
RhoA	G17V	Angioimmunoblastic T-cell lymphomas34,35
RhoH	Rearrangement	Non-Hodgkin’s lymphomas, multiple myeloma37
	Point mutation	Diffuse large B-cell lymphoma36