Figure 1.

Simplified model of the genetic regulation of conidiation. Only some of the regulators studied in this work are shown for clarity. FluG is responsible for the synthesis of an extracellular factor that induces the rest of the fluffy genes in the three parallel routes. FlbE (not shown) interacts and activates FlbB. FlbB and FlbD are transcription factors that jointly bind to the promoter of brlA, activating its transcription. FlbC is another transcription factor activating the expression of brlA. FlbA is a regulator of G-protein activity that positively regulates the transcription of brlA. Activation of brlA is necessary and sufficient to induce conidiation. Ovals indicate the promoter regions, and in front of brlA correspond to the two sites analyzed by ChIP.