Figure 2.

Identification of the molecular lesions of eight Enhancers of CCT. (A–H) Protein domain composition (according to the Conserved Domains tool at the National Center for Biotechnology Information) of proteins encoded by loci not previously identified in RTK/RAS-dependent modifier screens is shown. To confirm allelism between the complementation groups and the assigned loci, exon sequences for at least two heterozygous mutations for each group were determined. Mutations in the expected locus were found for each group. The position of the resulting amino acid lesion for each sequenced allele is shown on the protein schematics. “@” denotes STOP codons.