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Increased alcohol preference in Ap3m2 (−/−) knockout mice. Alcohol preference in B6.129P2-Ap3m2tm1Ohno/EJC [Ap3m2 (−/−)] was evaluated using the two-bottle water vs. ethanol choice test with increasing concentrations of ethanol every 4 days for 20 days. The Ap3m2 (−/−) mice had significantly higher preference for ethanol than the wild-type littermates across concentrations (between groups F(1,36) = 4.8646, P = 0.0339).
