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. 2013 Nov 14;56(24):9982–10002. doi: 10.1021/jm401251p

Figure 1.

Figure 1

PC-BSA protects against CIA and targets IL-17 and IFNγ responses. Arthritis scores (BSA, n = 7; PC-BSA, n = 6 (A)) and hind paw width (B), expressed as mean scores ± SEM for BSA- or PC-BSA-treatment groups where n = number of individual mice exposed to collagen and disease incidence (C,D), indicated by the % of mice developing a severity score ≥2 (C) or ≥4 (D). Serum IL-17 levels are plotted as mean values of triplicate IL-17 analyses of serum from individual mice (naïve, n = 3; BSA, n = 6; PC-BSA, n = 6 (E)). (F,G) Exemplar plots of gating strategy of intracellular IL-17 and IFNγ expression by DLN (draining lymph node) cells pooled from BSA- and PC-BSA-treated mice with CIA show CD4 or γδ expression on the x-axis versus cytokine expression on the y-axis, with the relevant % cytokine positive cells annotated. The numbers of cytokine-expressing CD4+ T cells (H,J), γδ T cells (I,L), and CD8+ T cells (K) present in the pooled DLN cells from the naïve (not exposed to collagen), BSA, and PC-BSA groups are shown. For statistical analysis, *p < 0.05.