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. 2013 Nov 14;56(24):9982–10002. doi: 10.1021/jm401251p

Figure 6.

Figure 6

11a suppresses IFNγ and IL-17 responses in CIA. Exemplar plots of gating strategy of intracellular IFNγ (A) and IL-17 (B) expression by DLN cells from representative individual PBS-treated mice with CIA show forward scatter (FSC) or CD4, CD8, and γδ expression on the y-axis versus cytokine expression on the x-axis as indicated. The number of (A) IFNγ-expressing total DLN cells, CD8+ T cells, and CD4+ T cells and (B) IL-17-expressing total DLN cells, CD4+ T cells, and γδ T cells following stimulation with PMA/ionomycin from individual mice are shown (naïve, n = 7; PBS, n = 13; 11a, n = 13). For statistical analysis, **p < 0.01 and ***p < 0.001.