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. Author manuscript; available in PMC: 2014 Aug 7.
Published in final edited form as: Semin Immunol. 2009 Jun 6;21(4):185–193. doi: 10.1016/j.smim.2009.05.005

Figure 2. Regulation of TLR-mediated type I IFN production in plasmacytoid DCs, by mTOR.

Figure 2

CpG or viral mediated activation of TLR9 leads to recruitment of MyD88 and TRAF6, and subsequent phosphorylation of IRF7, which promotes its translocation to the nucleus resulting in transcriptional activation of type I IFN genes. PI3K-AKT- signaling pathway activates mTOR which in-turn promotes TLR9-MyD88 complex formation through S6K phosphorylation and activation. Simultaneously, mTOR-mediated phosphorylation of 4E-BP results in dissociation of eukaryotic translation initiation factor (eIF)4E which binds to eIF4G/eIF4A complex and thus initiates more translation of IRF7 mRNA.