. Author manuscript; available in PMC: 2015 Jun 27.

Published in final edited form as: J Mol Microbiol Biotechnol. 2014 Jun 27;24(3):161–190. doi: 10.1159/000363506

Table 3.

Bifunctional proteins that can form integral membrane channels.

TC #	Family Name	Family Abbreviation	Average Size (# of aa)	Predicted # TMSs	Function 1	Function 2	Organism Type
TC #	Family Name	Family Abbreviation		Predicted # TMSs	Non-Channel	Channel	Organism Type
1.A.15	Non-Selective Cation Channel-2	NSCC		~340	2 TMSs	Component of the general secretory pathway, Sec 62.	Cation-specific channels	Eukaryotes
1.A.21	Bcl-2	Bcl-2	~230	1 TMS	Cell death	Cell anti-death	Mammalian cells
1.A.27	Phospholemman	PLM	178	1 TMS	Na⁺, K⁺-ATPase regulator	Intracellular organic and inorganic anion channels	Animals
1.A.37	CD20 Ca2⁺ Channel	CD20	~300	4 TMSs	IgE receptor,β-subunit	Ca2⁺ channels	Animals
1.A.48	Anion Channel-forming Bestrophin	Bestrophin	572	4 TMSs	Regulates L-type Ca2⁺ Channels	Anion channels	Animals
1.A.50	Phospholamban	PLB	52	1 TMS	Regulates Ca2⁺ ATPase	Ca2⁺ channels	Animals
1.A.54	Presenilin E.R. Ca2⁺ Leak Channel	Presenilin	444	9 TMSs	Protease (produces amyloid peptides)	Ca2⁺ channels	Ubiquitous
1.A.64	Plasmolipin	Plasmolipin	180	4 – 8 TMSs	Regulates NKCC2 (TC # 2.A.30.1.1); stabilizes kidney apical membranes; facilitates protein sorting	Voltage-dependent K⁺ channels	Animals