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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Biochim Biophys Acta. 2014 May 27;1842(9):1587–1595. doi: 10.1016/j.bbadis.2014.05.015

Figure 4. Leptin induced reduction in Aβ levels is partially contingent on SIRT1 activation.

Figure 4

(a,b) ELISA immunoassay clearly demonstrates that leptin significantly decreases the levels of intracellular Aβ42 and Aβ40, while concomitant treatment with the SIRT1 inhibitor sirtinol mitigates the leptin-induced decrease in intracellular Aβ42 and Aβ40. (c,d) ELISA immunoassay clearly shows that leptin significantly decreases the levels of secreted forms of Aβ42 and Aβ40, while co-treatment with the SIRT1 inhibitor sirtinol significantly attenuates the leptin-induced decrease in secreted Aβ42 and Aβ40. Data is expressed as Mean + S.E.M and includes determinations made in four separate cell culture experiments (n=4). *p<0.05, **p<0.01, ***p<0.001 versus control; † p<0.05, †† p<0.01 versus leptin.