Fig. 5. A single administration of PG16 protected SCID-hu Thy/Liv mice from challenge with clade A HIV_92/RW/008 but not clade C HIV_98/IN/022.

(A) HIV RNA was reduced by ~1 log₁₀ in mice treated with a single administration of 5–50 µg PG16 the day before inoculation with HIV_92/RW/008, unlike mice treated once by oral gavage with high-dose Truvada (2,000 mg/kg TDF plus 1,300 mg/kg FTC), which had no reductions in viral RNA 42 days after inoculation. (B) No reductions in HIV RNA were observed in mice treated with a single administration of 1.5–50 µg PG16 the day before inoculation with HIV_98/IN/022. The columns represent means, and the open circles represent individual mice. **P<0.01, *P<0.05 compared to untreated HIV-infected mice by the Mann-Whitney U test. The dotted line indicates the HIV RNA detection limit. (10^1.5 copies per 10⁶ implant cells).