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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: DNA Repair (Amst). 2014 Jun 30;21:78–86. doi: 10.1016/j.dnarep.2014.05.012

Figure 5. Atm and Aag interact in response to induced alkylation damage.

Figure 5

A) Ex vivo alkylation sensitivity of BM cells to methyl methanesulfonate (MMS). BM cells were derived from wild type (closed squares), Aag−/− (closed triangle), Atm−/− (open squares) and Aag−/− Atm−/− (open triangle) mice. Experiments were done a minimum of three times each, data are mean ± SEM.. B) Synergistic interaction between Mgmt and Atm in response to MNU treatment. Ex vivo alkylation sensitivity of BM cells to methyl nitrosourea (MNU). BM cells were derived from wild type (closed squares), Mgmt−/− (closed circles), Atm−/− (open squares) and Mgmt−/− Atm−/− (open circles) mice. Experiments were done a minimum of three times each, data are mean ± SEM.