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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Nat Struct Mol Biol. 2014 Jul 13;21(8):679–685. doi: 10.1038/nsmb.2857

Figure 3. Structure of the ROQ domain of human Roquin in complex with the CDE of TNF-α mRNA.

Figure 3

(a). Two views of the structure of the ROQ domain of human Roquin in complex with the TNF23 RNA. Only half of the TNF23 RNA duplex is shown. (b). Overview of the interface between TNF23 RNA (orange) and the ROQ domain (yellow and cyan). (c). Interactions between the 5′ arm of TNF23 and domain II of the ROQ domain. Water molecules are shown as red spheres. (d). Interactions between the 3′ arm of TNF23 and domain I of the ROQ domain