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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Cancer Discov. 2014 May 27;4(8):896–904. doi: 10.1158/2159-8290.CD-13-0230

Figure 2. PARP inhibition induces a differential response in vivo with a modest effect on overall tumor response.

Figure 2

(A) SA-β-gal staining in prostates of 8 week old Ptenpc−/− mice upon Olaparib (n=3) or vehicle (n=3) treatment for 2 weeks. (B) Quantification of SA-β-gal positivity from (A) (*p=0.0419). (C) Histopathological analysis of HGPIN status from (A). (D) H&E staining of DLP tumors from 4 month old Ptenpc−/−;Trp53pc−/− mice upon Olaparib (n=3) or vehicle (n=3) treatment for 1 week. (E) TUNEL staining to visualize apoptosis induction in (D) and (F) its quantification (***p=0.0006). (G) Histopathological analysis of HGPIN status from (D).