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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Physiol Behav. 2014 Feb 6;0:15–21. doi: 10.1016/j.physbeh.2014.01.017

Table 2.

Key features of two types of obesity Drosophila models [8, 37–40]

Approaches and
obese features		 Genetic models Diet induced models
Approaches overexpress energy fostering genes; down-regulate negative-regulation genes of energy balance (example: refs. 37) high fat, high sugar, and high proteins in diets (example: refs: 38–40)
Fat deposition Increase TAG Increase fat body size and lipid droplets Increase TAG Increase fat body and lipid droplets
Glucose NTD increase
Body weight Increase in adult fly NTD (larva) Increase in larva NTD (adult fly)
Insulin resistance NTD Yes
Activity(geotaxic) No change decrease
Food intake increase NTD
Heart Dsyfunction NTD Yes
*

NTD, not determined