Table I.
Baseline characteristics in the matched cohort, stratified by baseline eGFR category and initial revascularization with multivessel CABG versus PCI
| eGFR ≥60
|
eGFR 45–59
|
eGFR <45
|
||||
|---|---|---|---|---|---|---|
| CABG
|
PCI
|
CABG
|
PCI
|
CABG
|
PCI
|
|
| n = 2628 | n = 2628 | n = 941 | n = 941 | n = 517 | n = 517 | |
| Demographics | ||||||
| Mean (SD) age, y | 62.3 (9.4) | 62.3 (9.4) | 70.6 (7.9) | 70.7 (8.0) | 74.5 (7.5) | 74.4 (7.5) |
| Women, % | 18.8 | 18.8 | 25.2 | 25.2 | 41.0 | 41.0 |
| Race, % | ||||||
| White | 73.4 | 73.7 | 80.7 | 81.4 | 77.6 | 80.1 |
| Black | 6.0 | 5.1 | 3.3 | 3.6 | 4.6 | 6.2 |
| Asian | 11.2 | 11.7 | 9.0 | 8.0 | 10.3 | 8.1 |
| Other/unknown | 9.5 | 9.6 | 7.0 | 7.0 | 7.5 | 5.6 |
| Hispanic ethnicity, % | 13.1 | 13.1 | 11.2 | 10.3 | 13.7 | 12.6 |
| Comorbid conditions, % | ||||||
| Current or former smoker | 35.9 | 35.0 | 31.8 | 33.2 | 33.8 | 33.3 |
| MI on index presentation | 24.0 | 29.0 | 22.6 | 26.8 | 29.0 | 30.9 |
| Cardiovascular history | ||||||
| Myocardial infarction | 32.5 | 35.3 | 32.4 | 36.9 | 44.5 | 41.8 |
| Unstable angina | 25.9 | 24.4 | 24.7 | 25.3 | 23.4 | 25.7 |
| Heart failure | 5.4 | 3.5 | 8.5 | 11.3 | 16.6 | 19.3 |
| Cerebrovascular disease | 10.3 | 9.1 | 13.8 | 17.2 | 22.1 | 22.2 |
| Stroke/transient ischemic attack | 2.1 | 2.1 | 3.6 | 3.8 | 6.6 | 5.4 |
| Peripheral arterial disease | 3.1 | 2.7 | 5.0 | 4.7 | 9.1 | 7.2 |
| Mitral and/or aortic valve disease | 3.8 | 2.9 | 6.2 | 7.7 | 7.4 | 9.3 |
| Rheumatic heart disease | 0.1 | 0.1 | 0.0 | 0.1 | 0.4 | 0.4 |
| Atrial fibrillation/flutter | 5.3 | 4.8 | 9.5 | 10.4 | 11.4 | 13.2 |
| Ventricular fibrillation/tachycardia | 1.0 | 1.3 | 1.7 | 2.1 | 1.7 | 2.3 |
| Other medical history, % | ||||||
| Diabetes mellitus | 34.6 | 34.6 | 30.8 | 30.8 | 44.3 | 44.3 |
| Hypertension | 55.7 | 55.9 | 68.0 | 68.7 | 83.8 | 80.5 |
| Dyslipidemia | 87.8 | 88.1 | 88.8 | 87.8 | 88.0 | 89.0 |
| Dementia | 0.5 | 0.3 | 1.0 | 1.2 | 1.5 | 1.2 |
| Depression | 9.7 | 10.7 | 11.8 | 12.0 | 10.8 | 15.9 |
| Chronic liver disease | 1.5 | 1.5 | 1.0 | 1.4 | 0.2 | 1.0 |
| Chronic lung disease | 16.9 | 17.0 | 18.6 | 19.7 | 18.0 | 25.5 |
| Hyperthyroidism | 0.6 | 0.5 | 0.4 | 0.4 | 0.0 | 1.0 |
| Hypothyroidism | 8.5 | 8.4 | 13.9 | 14.0 | 15.7 | 20.9 |
| Systemic cancer | 7.4 | 8.2 | 13.2 | 12.3 | 14.3 | 15.1 |
| Hospitalized bleed | 1.6 | 1.1 | 2.4 | 2.2 | 3.1 | 3.5 |
| Arthritis | 0.4 | 0.4 | 0.7 | 0.7 | 0.2 | 1.4 |
| Laboratory values, % | ||||||
| Urinary dipstick protein excretion | ||||||
| None | 95.2 | 95.5 | 93.3 | 94.2 | 81.8 | 80.6 |
| +1 | 2.8 | 2.7 | 4.7 | 3.1 | 7.9 | 7.2 |
| +2 | 1.5 | 1.4 | 1.4 | 2.1 | 5.8 | 5.8 |
| +3 or +4 | 0.5 | 0.4 | 0.6 | 0.6 | 4.4 | 6.4 |
| Median (IQR) HDL, mg/dL, | 41 (36–49) | 42 (36–49) | 42 (37–51) | 42 (36–50) | 42 (35–51) | 42 (35–50) |
| Median (IQR) LDL, mg/dL, | 119 (94–149) | 115 (93–145) | 109 (90–139) | 111 (88–139) | 105 (85–131) | 104 (82–130) |
| Hemoglobin, g/L, Median (IQR) | 14.5 (13.5–15.3) | 14.5 (13.5–15.3) | 14.0 (13.0–14.9) | 14.2 (13.0–15.0) | 13.0 (11.8–14.2) | 12.9 (11.8–14.1) |
| Baseline medication use | ||||||
| Angiotensin-converting enzyme inhibitor | 35.8 | 34.6 | 40.8 | 40.4 | 48.2 | 49.3 |
| Angiotensin II receptor blocker | 5.8 | 5.4 | 8.2 | 8.2 | 7.4 | 14.1 |
| Aldosterone receptor antagonist | 0.7 | 0.6 | 1.8 | 1.6 | 2.3 | 4.8 |
| β-Blocker | 53.9 | 52.0 | 59.6 | 57.9 | 65.8 | 64.8 |
| Calcium-channel blocker | 19.1 | 18.9 | 27.3 | 28.4 | 42.0 | 40.6 |
| Diuretic | 26.8 | 26.5 | 40.4 | 41.1 | 62.5 | 63.2 |
| Hydralazine | 0.9 | 0.5 | 2.4 | 1.9 | 7.9 | 7.4 |
| Nitrates | 24.8 | 23.3 | 30.9 | 30.1 | 34.2 | 31.7 |
| α-Adrenergic receptor antagonist | 8.7 | 8.9 | 13.5 | 15.5 | 22.6 | 19.9 |
| Digoxin | 3.5 | 2.7 | 5.8 | 6.2 | 7.9 | 8.5 |
| Statins | 52.0 | 49.6 | 56.2 | 54.1 | 61.7 | 61.5 |
| Other lipid-lowering agent | 5.9 | 6.0 | 6.7 | 6.2 | 8.7 | 6.2 |
| Anti-inflammatory agent | 18.2 | 19.7 | 18.5 | 20.9 | 13.9 | 18.6 |
| Aspirin | 6.3 | 5.8 | 7.3 | 6.7 | 9.1 | 8.3 |
| Other antiplatelet agent | 4.0 | 4.6 | 5.5 | 3.9 | 7.7 | 7.7 |
| Diabetic therapy | 27.1 | 27.4 | 24.5 | 24.2 | 37.3 | 36.6 |
All values are percentages, except where otherwise noted.