Table 2.
Percentage of Cervical Biopsy Specimens With Cervical Intraepithelial Neoplasia Grade 2 (CIN2) Diagnoses by Laboratory, Stratified by Preceding Cytology and Agea
| Total | Total CIN2, No. (%) | Preceding Cytology, No. (% CIN2)
|
No. (% CIN2) by Age
|
|||||
|---|---|---|---|---|---|---|---|---|
| None | Normal/ASC-US/LSIL | HSIL+ | 14–24 y | 25–39 y | 40–86 y | |||
| Total | 37,486 | 4,547 (12.1) | 4,100 (11.5) | 26,380 (10.4) | 6,909 (19.4) | 14,332 (14.1) | 15,396 (13.7) | 7,740 (5.4) |
| Laboratory | ||||||||
| A | 673 | 83 (12.3) | 112 (12.5) | 433 (12.0) | 128 (13.3) | 279 (16.8) | 287 (10.8) | 107 (4.7) |
| B | 3,733 | 266 (7.1) | 310 (8.1) | 2,378 (5.2) | 1,036 (11.4) | 1,192 (10.5) | 1,508 (7.4) | 1,033 (2.8) |
| C | 374 | 55 (14.7) | 90 (16.7) | 240 (14.2) | 44 (13.6) | 191 (14.7) | 121 (20.7) | 62 (3.2) |
| D | 5,185 | 396 (7.6) | 508 (6.5) | 3,942 (6.2) | 729 (15.9) | 2,265 (7.7) | 1,941 (9.1) | 979 (4.6) |
| E | 1,680 | 196 (11.7) | 392 (11.7) | 992 (8.7) | 287 (22.3) | 481 (14.6) | 744 (13.4) | 445 (5.6) |
| F | 457 | 53 (11.6) | 175 (6.9) | 232 (12.5) | 50 (24.0) | 213 (12.7) | 164 (11.6) | 80 (8.8) |
| G | 422 | 42 (10.0) | 51 (7.8) | 302 (8.6) | 68 (17.6) | 156 (8.3) | 191 (12.6) | 75 (6.7) |
| H | 794 | 86 (10.8) | 72 (12.5) | 536 (8.4) | 185 (17.3) | 370 (11.6) | 263 (13.7) | 161 (4.3) |
| I | 2,948 | 267 (9.1) | 389 (5.9) | 2,069 (7.5) | 484 (18.2) | 1,013 (11.5) | 1,217 (9.7) | 717 (4.6) |
| J | 308 | 52 (16.9) | 119 (21.0) | 138 (12.3) | 44 (18.2) | 141 (18.4) | 121 (18.2) | 46 (8.7) |
| K | 746 | 88 (11.8) | 124 (11.3) | 561 (10.3) | 59 (27.1) | 292 (13.7) | 377 (11.9) | 77 (3.9) |
| L | 16,813 | 2,422 (14.4) | 1,180 (11.6) | 12,256 (12.8) | 3,365 (21.3) | 6,401 (17.0) | 7,011 (16.1) | 3,401 (6.1) |
| M | 1,161 | 124 (10.7) | 108 (13.9) | 874 (8.2) | 149 (23.5) | 455 (9.7) | 482 (14.1) | 224 (5.4) |
| N | 1,848 | 412 (22.3) | 443 (22.1) | 1,160 (18.8) | 231 (40.3) | 705 (25.0) | 849 (23.2) | 287 (12.5) |
| O | 344 | 5 (1.5) | 27 (0.0) | 267 (1.1) | 50 (4.0) | 178 (1.7) | 120 (1.7) | 46 (0.0) |
ASC-US, atypical squamous cells of undetermined significance; HSIL, high-grade squamous intraepithelial lesion; LSIL, low-grade squamous intraepithelial lesion.
a
Percent distribution of CIN2 was statistically different in all subgroups between laboratories (P < .001).