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Model depicting the mechanism by which HMGB1 modulates docetaxel resistance by regulating autophagy. Docetaxel promotes the cytosolic translocation of HMGB1. Cytosolic HMGB1 acts as an activator of autophagy, which potentiates the formation of the Beclin-1-PI3K-III complex through activating the MEK/ERK1/2 signaling pathway. PI3K-III also serves as an upstream signal of MEK/ERK1/2 for facilitating the core complex formation.
