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. 2014 Jul 21;35(8):1074–1081. doi: 10.1038/aps.2014.55

Figure 2.

Figure 2

The screening results of the anti-HCV replicon assay. 1200 synthetic compounds with novel structure were screened by using the HCV subgenomic replicon-based reporter cell line (J399LM, genotype 2a). Compounds were co-cultured with cells for 48 h. The luciferase signal was read and compared to control wells without compounds. Compounds with reporter signal lower than the mean-3xSD (lower dashed line) of control wells (without compound) were considered to be active compounds and selected for further tests. Normal Huh7.5.1 cells served as the blank.