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| Compound | NS3/4A-Seap assay |
|||
|---|---|---|---|---|
| CC50 (μmol/L) | IC50 (μmol/L) | SI | ||
| 2,4-Diaminoquinazoline derivatives | HZ-1031 | >10 | 0.037±0.013 | >136 |
| HZ-1031 | >10 | >10 | ||
| HZ-1157 | 14±0.15 | 1.0±0.92 | 14 | |
| HZ-1327 | 5.5±0.26 | 4.2±0.16 | 1.3 | |
| HZ-1600 | >10 | >10 | ||
| Carboxamide analogues | LZ-110618-1 | 9.3±0.87 | 9.1±0.51 | 1.0 |
| LZ-110618-6 | 15±0.93 | 0.68±0.071 | 22 | |
| LZ-110618-9 | 10±1.2 | 6.1±0.71 | 1.6 | |
| LZ-121012-24 | 8.6±0.62 | 5.5±0.52 | 1.5 | |
| VX-950 | >10 | 1.0±0.33 | >10 | |
