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. 2014 Aug 8;8:225. doi: 10.3389/fncel.2014.00225

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Copyright © 2014 Peng, Liu, Tang, Liu, Han, Han, Li, Hou, Liu and Long.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HFD improved microarchitecture of femur trabecular bone in APP/PS1 mice. The volumetric BMD [vBMD (A)], tissue BMD [tBMD (B)], and trabecular thickness [Tb.Th (F)] were not significantly altered in C57BL/6 mice and APP/PS1 mice; however, these parameters significantly increased after HFD. Bone volume fraction [BV/TV (D)] was lower in APP/PS1 mice and recovered after HFD feeding. No significant differences in BMC (C) or trabecular number [Tb. N (E)] were found among the three groups. The trabecular separation [Tb.Sp (G)] was not significantly altered in C57BL/6 mice or APP/PS1 mice, and it was reduced after HFD. Micrographs showed the microarchitecture of femoral trabecule (H) with arrows indicating the representative part. Data were means ± SEM. n = 7 for C57BL/6 mice, n = 8 for APP/PS1 mice, and n = 8 for APP/PS1 + HFD mice. The results were analyzed by one-way ANOVA, followed by Newman–Keuls post hoc test. *p < 0.05; **p < 0.01.