Table 3. Genotype frequencies of miR-27a, miR-146a, miR-196a-2, miR-492, miR-608 SNPs in controls and colorectal cancer patients.

		Controls (n = 428)		CRC (n = 193)
SNP	Genotypes/Alleles	n	%	n	%	aOR	95% CI	P value
miR-27a T>Ca	TT	203	47.4	87	45.5	1
rs895819	TC	191	44.6	79	41.4	0.94	(0.65–1.36)	0.736
	CC	34	7.9	25	13.1	1.68	(0.93–3.02)	0.084
	TT vs. TC + CC					1.05	(0.74–1.48)	0.790
	TT + TC vs. CC					1.73	(0.99–3.03)	0.055
	Allele T	597	69.7	253	66.2	1
	Allele C	259	30.3	129	33.8	1.18	(0.91–1.52)	0.219
miR-146a G>Cb	GG	275	64.9	140	72.9	1
rs2910164	GC	134	31.6	50	26.0	0.76	(0.51–1.12)	0.163
	CC	15	3.5	2	1.0	0.20	(0.06–1.23)	0.092
	GG vs. GC + CC					0.71	(0.48–1.04)	0.078
	GG + GC vs. CC					0.30	(0.07–1.33)	0.113
	Allele G	684	80.7	330	85.9	1
	Allele C	164	19.3	54	14.1	0.68	(0.49–0.95)	0.025
miR-196a-2 C>Tc	CC	199	46.6	79	40.9	1
rs11614913	CT	174	40.8	87	45.1	1.28	(0.88–1.86)	0.193
	TT	54	12.6	27	14.0	1.25	(0.73–2.14)	0.420
	CC vs. CT + TT					1.27	(0.90–1.81)	0.177
	CC + CT vs. TT					1.10	(0.67–1.83)	0.700
	Allele C	572	67.0	245	63.5	1
	Allele T	282	33.0	141	36.5	1.17	(0.91–1.50)	0.228
			428
miR-492 G>C	GG	377	88.1	159	82.4	1
rs2289030	GC	49	11.4	32	16.6	1.58	(0.97–2.59)	0.068
	CC	2	0.5	2	1.0	2.36	(0.32–17.38)	0.401
	GG vs. GC + CC					1.61	(1.00–2.61)	0.052
	GG + GC vs. CC					2.21	(0.30–16.28)	0.436
	Allele G	803	93.8	350	90.7	1
	Allele C	53	6.2	36	9.3	1.56	(1.00–2.42)	0.047
miR-608 C>Gd	CC	318	74.7	138	71.9	1
rs4919510	CG	96	22.5	47	24.5	1.12	(0.74–1.68)	0.592
	GG	12	2.8	7	3.6	1.36	(0.52–3.59)	0.533
	CC vs. CG + GG					1.15	(0.78–1.69)	0.495
	CC + CG vs. GG					1.33	(0.50–3.48)	0.568
	Allele C	732	85.9	323	84.1	1
	Allele G	120	14.1	61	15.9	1.15	(0.82–1.61)	0.407

CRC – colorectal cancer; aOR – adjusted odds ratio (age, sex, country); CI – confidence interval;

^atwo individuals failed to be genotyped for rs895819;

^bfive individuals failed to be genotyped for rs2910164;

^cone individuals failed to be genotyped for rs11614913;

^dthree individuals failed to be genotyped for rs4919510.