Table 1.
Treatment Group | ||||
---|---|---|---|---|
FLAG N=22 |
FA N=45 |
IA± G-CSF N=47 |
||
Parameters | Median (Range) | Median (Range) | Median (Range) | P value |
Age | 39 (18–74) | 47 (18–80) | 36 (16–83) | 0.33 |
Sex (Male/Female) | 10/12 | 20/25 | 29/18 | 0.20 |
ECOG PS | 1 (0–2) | 1 (0–4) | 1 (0–4) | 0.02 |
WBC | 7.4 (1.1–91) | 13 (0.6–93) | 23.4 (1–226.5) | 0.06 |
Platelet count | 38 (6–119) | 40 (12–330) | 38 (6–183) | 0.98 |
Hemoglobin | 8.1 (3.4–11.9) | 8.1 (2.5–13.1) | 8.4 (3.7–12.3) | 0.68 |
Creatinine | 0.85 (0.6–1.2) | 0.8 (0.5–2.8) | 0.9 (0.6–2.9) | 0.71 |
Total Bilirubin | 0.5 (0.3–1.5) | 0.5 (0.1–4.7) | 0.6 (0.2–2.2) | 0.23 |
Percentage bone marrow blast | 42 (30–80) | 51 (10–86) | 54 (20–94) | 0.43 |
Cytogenetics (N) | ||||
INV 16/T(8;21) | 13/9 | 36/9 | 32/15 | 0.55 |
Abbreviations:
FLAG= fludarabine, cytarabine and G-CSF
FA= fludarabine, cytarabine
IA= idarubicin, cytarabine
ECOG= Eastern Co-operative Oncology Group
PS= performance status