Table 2. Spearman's correlations of baseline clinical and MRI indices with annual accrual rate of WMH.
| Variables | rho | P |
|---|---|---|
| Thalamus FA | 0.366 | 0.006* |
| Thalamus MD | 0.173 | 0.202 |
| Caudate FA | 0.230 | 0.088 |
| Caudate MD | 0.237 | 0.079 |
| Putamen FA | 0.034 | 0.806 |
| Putamen MD | 0.283 | 0.035 |
| Age | −0.042 | 0.761 |
| Sex | −0.197 | 0.147 |
| 24-hour SBP (mm Hg) | −0.022 | 0.881 |
| 24-hour DBP (mm Hg) | 0.099 | 0.490 |
| Diabetes | −0.149 | 0.273 |
| BMI (kg/m2) | −0.220 | 0.104 |
| Total cholesterol (mg/dL) | 0.035 | 0.799 |
| LDL (mg/dL) | −0.002 | 0.989 |
| HDL (mg/dL) | −0.094 | 0.490 |
| Baseline WMH volume (mL) | 0.577 | 0.00001 |
| Lacunes count | 0.270 | 0.044 |
Abbreviations: BMI, body mass index; DPB, diastolic blood pressure; DTI, diffusion tensor imaging; FA, fractional anisotropy; HDL, high-density lipoprotein cholesterol; LDL, low-density lipoprotein cholesterol; MD, mean diffusivity; MRI, magnetic resonance imaging; SBP, systolic blood pressure; WMH, white matter hyperintensity.
Threshold for statistical significance for analyses involving other variables was 0.05. Statistical significance is indicated in bold. According to the primary study aim, we applied Bonferroni correction for multiple comparisons, which resulted in a threshold for statistical significance ≤0.0083 (0.05/6) for the analyses involving DTI measurements of the three structures of interest. P-values ≤0.05 are indicated in bold; (*) indicates P-values ≤0.0083.