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. 2014 May 21;34(8):1391–1401. doi: 10.1038/jcbfm.2014.95

Figure 1.

Figure 1

A failure of IEX-1 KO mice to fully recover from mTBI. (A) Representative photos of sham and mildly injured brains of WT and KO mice. The photos were taken at 6 hours after the mild injury showing erythema, marked in a white dash line circle, on the impact scalp (upper), with normal skull (middle) and brain (lower) underneath. (B) A time course of NSS after mTBI. NSS was assessed in WT and KO mice at 1 hour and indicated days after mTBI and expressed as means±s.e.m. (C) Body weight changes over time in injured mice. A health status of the animals was monitored by weighing the animals at the indicated days after mTBI and expressed as means±s.e.m. of body weight changes relative to a preinjury level that sets arbitrarily as 1. *P<0.05 and ***P<0.001 in the presence or absence of IEX-1 (n=9 mice per group). IEX-1, immediate early responsive gene X-1; KO, knockout; mTBI, mild traumatic brain injury; NSS, neurologic severity score; WT, wild-type.