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Impact of IFNL on Th1/Th2 cytokine profiling. The IFNL3 major allele genotype shows a predominant polarization to a macrophage M1 phenotype, whereas the minor allele genotype may show a relative increase of M2 phenotype. These macrophage phenotypes are associated with the downstream regulation and polarization of Th1 and Th2 cells. NK cells, natural killer cells.
